S1P; SGPP1; SGPP2; Inflammatory Bowel Disease

Sphingosine-1-phosphate phosphatase 2 promotes disruption of mucosal integrity, and contributes to ulcerative colitis in mice and humans

The bioactive sphingolipid sphingosine-1-phosphate (S1P) and the kinase that produces it have been implicated in inflammatory bowel …

Wei-Ching Huang, Jie Liang, Masayuki Nagahashi, Dorit Avni, Akimitsu Yamada, Michael Maceyka, Aaron R Wolen, Tomasz Kordula, Sheldon Milstien, Kazuaki Takabe, Tamas Oravecz, Sarah Spiegel