publications. | Aaron Wolen

osfr: An R Interface to the Open Science Framework

An R interface to the Open Science Framework.

Aaron R Wolen, Chris Hartgerink, Ryan Hafen, Brian Richards, Courtney K Soderberg, Timothy P York

Adducins inhibit lung cancer cell migration through mechanisms involving regulation of cell-matrix adhesion and cadherin-11 expression

Cell migration is a critical mechanism controlling tissue morphogenesis, epithelial wound healing and tumor metastasis. Migrating cells …

Susana Lechuga, Parth H Amin, Aaron R Wolen, Andrei I Ivanov

Cross-species alcohol dependence-associated gene networks: Co-analysis of mouse brain gene expression and human genome-wide association data

Genome-wide association studies on alcohol dependence, by themselves, have yet to account for the estimated heritability of the …

Kristin M Mignogna, Silviu a Bacanu, Brien P Riley, Aaron R Wolen, Michael F Miles

Incorporating Functional Genomic Information to Enhance Polygenic Signal and Identify Variants Involved in Gene-by-Environment Interaction for Young Adult Alcohol Problems

BACKGROUND: Characterizing aggregate genetic risk for alcohol misuse and identifying variants involved in gene-by-environment (G × E) …

Jessica E Salvatore, Jeanne E Savage, Peter Barr, Aaron R Wolen, Fazil Aliev, Eero Vuoksimaa, Antti Latvala, Lea Pulkkinen, Richard J Rose, Jaakko Kaprio, Danielle M Dick

The allostatic impact of chronic ethanol on gene expression: A genetic analysis of chronic intermittent ethanol treatment in the BXD cohort

The transition from acute to chronic ethanol exposure leads to lasting behavioral and physiological changes such as increased …

Andrew D Van Der Vaart, Jennifer T Wolstenholme, Maren L Smith, Guy M Harris, Marcelo F Lopez, Aaron R Wolen, Howard C Becker, Robert W Williams, Michael F Miles

The Rate of Change in Alcohol Misuse Across Adolescence is Heritable

BACKGROUND: Alcohol use typically begins during adolescence and escalates into young adulthood. This represents an important period for …

Alexis C Edwards, Jon Heron, Vladimir Vladimirov, Aaron R Wolen, Daniel E Adkins, Fazil Aliev, Matthew Hickman, Kenneth S Kendler

Molecular Genetic Influences on Normative and Problematic Alcohol Use in a Population-Based Sample of College Students

Background: Genetic factors impact alcohol use behaviors and these factors may become increasingly evident during emerging adulthood. …

Bradley T Webb, Alexis C Edwards, Aaron R Wolen, Jessica E Salvatore, Fazil Aliev, Brien P Riley, Cuie Sun, Vernell S Williamson, James N Kitchens, Kimberly Pedersen, Amy Adkins, Megan E Cooke, Jeanne E Savage, Zoe Neale, Seung B Cho, Danielle M Dick, Kenneth S Kendler

Sphingosine-1-phosphate phosphatase 2 promotes disruption of mucosal integrity, and contributes to ulcerative colitis in mice and humans

The bioactive sphingolipid sphingosine-1-phosphate (S1P) and the kinase that produces it have been implicated in inflammatory bowel …

Wei-Ching Huang, Jie Liang, Masayuki Nagahashi, Dorit Avni, Akimitsu Yamada, Michael Maceyka, Aaron R Wolen, Tomasz Kordula, Sheldon Milstien, Kazuaki Takabe, Tamas Oravecz, Sarah Spiegel

Identification of quantitative trait loci and candidate genes for an anxiolytic-like response to ethanol in BXD recombinant inbred strains

Genetic differences in acute behavioral responses to ethanol contribute to the susceptibility to alcohol use disorder and the reduction …

A H Putman, A R Wolen, J L Harenza, R K Yordanova, B T Webb, E J Chesler, M F Miles

Time-Course Analysis of Brain Regional Expression Network Responses to Chronic Intermittent Ethanol and Withdrawal: Implications for Mechanisms Underlying Excessive Ethanol Consumption

Long lasting abusive consumption, dependence, and withdrawal are characteristic features of alcohol use disorders (AUD). …

Maren L Smith, Marcelo F Lopez, Kellie J Archer, Aaron R Wolen, Howard C Becker, Michael F Miles

Meta-analysis of genome-wide association studies of anxiety disorders

John Hettema, Takeshi Otowa, Karin Hek, Minyoung Lee, Enda Byrne, Saira Mirza, Michel Nivard, Tim Bigdeli, Steven Aggen, Daniel Adkins, Aaron R Wolen, Ayman Fanous, Matthew Keller, Enrique Castelao, Zoltan Kutalik, Sandra Van Der Auwera, Georg Homuth, Matthias Nauck, Alexander Teumer, Nese Jouke-Jan Hottenga Direk, Albert Hofman, André Uitterlinden, Cornelis Mulder, Anjali Henders, Sarah Medland, Scott Gordon, Andrew Heath, Pamela Madden, Michelle Pergadia, Peter Van Der Most, Ilja Nolte, Floor Van Oort, Catharina Hartman, Albertine Oldehinkel, Martin Preisig, Hans Joergen Grabe, Christel Middeldorp, Brenda W.J.H. Penninx, Dorret Boomsma, Nicholas Martin, Grant Montgomery, Brion Maher, Edwin Van Den Oord, Naomi Wray, Henning Tiemeier

Establishing an analytic pipeline for genome-wide DNA methylation

The need for research investigating DNA methylation (DNAm) in clinical studies has increased, leading to the evolution of new analytic …

Michelle L Wright, Mikhail G Dozmorov, Aaron R Wolen, Colleen Jackson-Cook, Angela R Starkweather, Debra E Lyon, Timothy P York

Integrating Genomic and Genetic Data Across Species to Identify Gene Networks Contributing to Ethanol Behaviors and Alcohol Use Disorder

Mouse genomic studies on acute or chronic ethanol exposure models have been previously used to identify gene networks and cognate hub …

Michael F Miles, Kristin M Mignogna, Aaron R Wolen, Brien P Riley

Incorporating Bioinformatics Data to Understand Alcohol-related GWAS Results

PURPOSE. Genome-wide association studies (GWAS) of alcohol dependence and genetically correlated externalizing disorders have produced …

Jessica Salvatore, Jeanne Savage, P. Barr, Mikhail Dozmorov, Aaron R Wolen, Fazil Aliev, FinnTwin12, COGA Collaborators, Danielle Dick

Genomic influences on alcohol problems in a population-based sample of young adults

AIMS: Alcohol problems (AP) contribute substantially to the global disease burden. Twin and family studies suggest that AP are …

Alexis C Edwards, Fazil Aliev, Aaron R Wolen, Jessica E Salvatore, Charles O Gardner, George McMahon, David M Evans, John Macleod, Matt Hickman, Danielle M Dick, Kenneth S Kendler

Biological insights from 108 schizophrenia-associated genetic loci

Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small …

Schizophrenia Working Group of the Psychiatric Genomics Consortium

Genomic influences on alcohol problems in a population-based sample of young adults

Alexis C Edwards, Aaron R Wolen, Fazil Aliev, Mark A. Reimers, Matt Hickman, Glyn Lewis, Danielle M. Dick, Kenneth S Kendler

Integrating genomic and genetic data suggests circuit development abnormalities in schizophrenia

It seems likely that the genetic contribution of common variants to the risk of major psychiatric disorders is distributed across at …

Aaron R Wolen, Kenneth S Kendler, Mark a Reimers

Role of Adrenal Glucocorticoid Signaling in Prefrontal Cortex Gene Expression and Acute Behavioral Responses to Ethanol

BACKGROUND: Glucocorticoid hormones modulate acute and chronic behavioral and molecular responses to drugs of abuse including …

Blair N Costin, Aaron R Wolen, Sylvia Fitting, Keith L Shelton, Michael F Miles

Genetic dissection of acute ethanol responsive gene networks in prefrontal cortex: functional and mechanistic implications

BACKGROUND: Individual differences in initial sensitivity to ethanol are strongly related to the heritable risk of alcoholism in …

Aaron R Wolen, Charles a Phillips, Michael a Langston, Alex H Putman, Paul J Vorster, Nathan a Bruce, Timothy P York, Robert W Williams, Michael F Miles

Genetic dissection of acute ethanol responsive gene networks in prefrontal cortex: functional and mechanistic implications

Identifying Gene Networks Underlying the Neurobiology of Ethanol and Alcoholism

For complex disorders such as alcoholism, identifying the genes linked to these diseases and their specific roles is difficult. …

Aaron R Wolen, Michael F Miles

Identifying Gene Networks Underlying the Neurobiology of Ethanol and Alcoholism

MicroRNA profiles in allograft tissues and paired urines associate with chronic allograft dysfunction with IF/TA

Despite the advances in immunosuppression, renal allograft attrition over time remains unabated due to chronic allograft dysfunction …

M J Scian, D G Maluf, K G David, K J Archer, J L Suh, A R Wolen, M U Mba, H D Massey, A L King, T Gehr, A Cotterell, M Posner, V Mas

Myelin gene expression: Implications for alcohol abuse and dependence

Sean P Farris, Aaron R Wolen, Michael F Miles

Intra- and inter-regional ethanol responsive gene networks of the mesolimbocortical reward pathway

Aaron R Wolen, Charles a Phillips, Michael a Langston, Alex H Putman, Paul J Vorster, Nathan a Bruce, Timothy P York, Robert W Williams, Lu Lu, Michael F Miles

Genetic dissection of an acute ethanol-induced anxiolysis QTL

JoLynne Harenza, Aaron R Wolen, Alex H Putman, Michael F Miles

Urine miRNA panel as accurate biomarkers for monitoring kidney graft function

Background. Improvement in short term outcomes in kidney transplantation (Tx) had been achieved. However, long-term outcomes have not …

D G Maluf, M J Scian, J L Suh, Aaron R Wolen, Kapoor S, M Posner, A Cotterell, A L King, V Mas

Elucidation of ethanol responsive gene networks in BXD recombinant inbred strains

Aaron R Wolen, Charles a Phillips, Michael a Langston, Alex H Putman, Robert W Williams, Lu Lu, Michael F Miles

Using expression genetics to study the neurobiology of ethanol and alcoholism

Recent simultaneous progress in human and animal model genetics and the advent of microarray whole genome expression profiling have …

Sean P Farris, Aaron R Wolen, Michael F Miles